全文获取类型
收费全文 | 25377篇 |
免费 | 1866篇 |
国内免费 | 169篇 |
专业分类
耳鼻咽喉 | 204篇 |
儿科学 | 587篇 |
妇产科学 | 471篇 |
基础医学 | 3575篇 |
口腔科学 | 259篇 |
临床医学 | 2279篇 |
内科学 | 5918篇 |
皮肤病学 | 329篇 |
神经病学 | 2501篇 |
特种医学 | 862篇 |
外国民族医学 | 1篇 |
外科学 | 4892篇 |
综合类 | 160篇 |
一般理论 | 9篇 |
预防医学 | 1534篇 |
眼科学 | 287篇 |
药学 | 1543篇 |
中国医学 | 76篇 |
肿瘤学 | 1925篇 |
出版年
2023年 | 112篇 |
2022年 | 84篇 |
2021年 | 449篇 |
2020年 | 362篇 |
2019年 | 599篇 |
2018年 | 653篇 |
2017年 | 496篇 |
2016年 | 546篇 |
2015年 | 633篇 |
2014年 | 890篇 |
2013年 | 1215篇 |
2012年 | 1828篇 |
2011年 | 1982篇 |
2010年 | 1202篇 |
2009年 | 1129篇 |
2008年 | 1730篇 |
2007年 | 1773篇 |
2006年 | 1668篇 |
2005年 | 1737篇 |
2004年 | 1533篇 |
2003年 | 1555篇 |
2002年 | 1567篇 |
2001年 | 230篇 |
2000年 | 176篇 |
1999年 | 227篇 |
1998年 | 269篇 |
1997年 | 267篇 |
1996年 | 179篇 |
1995年 | 216篇 |
1994年 | 170篇 |
1993年 | 167篇 |
1992年 | 135篇 |
1991年 | 122篇 |
1990年 | 116篇 |
1989年 | 92篇 |
1988年 | 92篇 |
1987年 | 74篇 |
1986年 | 105篇 |
1985年 | 91篇 |
1984年 | 93篇 |
1983年 | 96篇 |
1982年 | 102篇 |
1981年 | 90篇 |
1980年 | 87篇 |
1979年 | 59篇 |
1978年 | 46篇 |
1977年 | 38篇 |
1976年 | 40篇 |
1975年 | 35篇 |
1974年 | 35篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
61.
Romaric Loffroy Sylvain Favelier Pierre Pottecher Pierre-Yves Genson Louis Estivalet Sophie Gehin Jean-Pierre Cercueil Denis Krausé 《World journal of radiology》2015,7(7):143-148
Visceral artery aneurysms (VAA) include splanchnic and renal artery aneurysms. They represent a rare clinical entity, although their detection is rising due to an increased use of cross-sectional imaging. Rupture is the most devastating complication, and is associated with a high morbidity and mortality. In addition, increased percutaneous endovascular interventions have raised the incidence of iatrogenic visceral artery pseudoaneurysms (VAPAs). For this reason, elective repair is preferable in the appropriately chosen patient. Controversy still exists regarding their treatment. Over the past decade, there has been steady increase in the utilization of minimally invasive, non-operative interventions, for vascular aneurysmal disease. All VAAs and VAPAs can technically be fixed by endovascular techniques but that does not mean they should. These catheter-based techniques constitute an excellent approach in the elective setting. However, in the emergent setting it may carry a higher morbidity and mortality. The decision for intervention has to take into account the size and the natural history of the lesion, the risk of rupture, which is high during pregnancy, and the relative risk of surgical or radiological intervention. For splanchnic artery aneurysms, we should recognize that we are not, in reality, well informed about their natural history. For most asymptomatic aneurysms, expectant treatment is acceptable. For large, symptomatic or aneurysms with a high risk of rupture, endovascular treatment has become the first-line therapy. Treatment of VAPAs is always mandatory because of the high risk of rupture. We present our point of view on interventional radiology in the splanchnic arteries, focusing on what has been achieved and the remaining challenges. 相似文献
62.
Christine Lorut Aurélie Lefebvre Benjamin Planquette Laurent Quinquis Hervé Clavier Nicola Santelmo Halim Abou Hanna François Bellenot Jean-François Regnard Marc Riquet Pierre Magdeleinat Guy Meyer Nicolas Roche Marie-Pierre Revel Gérard Huchon Joel Coste Antoine Rabbat 《Intensive care medicine》2014,40(3):469-469
63.
Pierre Bedossa 《Digestive diseases and sciences》2016,61(5):1348-1355
64.
Amélie Huynh Le Maux Bernadette Pignol Delphine Behr-Roussel Jean-Luc Blachon Pierre-Etienne Chabrier Sandrine Compagnie Philippe Picaut Jacques Bernabé Fran?ois Giuliano Pierre Denys 《Toxins》2015,7(12):5462-5471
Intradetrusor injections of Botulinum toxin A—currently onabotulinumtoxinA—is registered as a second-line treatment to treat neurogenic detrusor overactivity (NDO). The common clinical practice is 30 × 1 mL injections in the detrusor; however, protocols remain variable and standardization is warranted. The effect of reducing the number of injection sites of Dysport® abobotulinumtoxinA (aboBoNTA) was assessed in the spinal cord-injured rat (SCI). Nineteen days post-spinalization, female rats received intradetrusor injections of saline or aboBoNTA 22.5 U distributed among four or eight sites. Two days after injection, continuous cystometry was performed in conscious rats. Efficacy of aboBoNTA 22.5 U was assessed versus aggregated saline groups on clinically-relevant parameters: maximal pressure, bladder capacity, compliance, voiding efficiency, as well as amplitude, frequency, and volume threshold for nonvoiding contractions (NVC). AboBoNTA 22.5 U significantly decreased maximal pressure, without affecting voiding efficiency. Injected in four sites, aboBoNTA significantly increased bladder capacity and compliance while only the latter when in eight sites. AboBoNTA significantly reduced NVC frequency and amplitude. This preclinical investigation showed similar inhibiting effects of aboBoNTA despite the number of sites reduction. Further studies are warranted to optimize dosing schemes to improve the risk-benefit ratio of BoNTA-based treatment modalities for NDO and further idiopathic overactive bladder. 相似文献
65.
Siwar Ayouni Khira Sdiri-Loulizi Alexis de Rougemont Marie Estienney Katia Ambert-Balay Serge Aho Sabeur Hamami Mahjoub Aouni Mohamed Neji-Guediche Pierre Pothier Ga?l Belliot 《Emerging infectious diseases》2015,21(11):2055-2058
To determine whether rotavirus infections are linked to secretor status, we studied samples from children in Tunisia with gastroenteritis. We phenotyped saliva for human blood group antigens and tested feces for rotavirus. Rotavirus was detected in 32/114 patients. Secretor genotyping showed that P[8] rotavirus infected secretors and nonsecretors, and infection correlated with presence of Lewis antigen. 相似文献
66.
Anne Caudron Maxime Battistella Jean‐Paul Feugeas Cécile Pages Nicole Basset‐Seguin Sarra Mazouz Dorval Elisa Funck Brentano Aurélie Sadoux Marie‐Pierre Podgorniak Suzanne Menashi Anne Janin Samia Mourah 《Experimental dermatology》2016,25(8):618-622
CD147 has been implicated in melanoma invasion and metastasis mainly through increasing metalloproteinase synthesis and regulating VEGF/VEGFR signalling. In this study, the prognostic value of CD147 expression was investigated in a cohort of 196 cutaneous melanomas including 136 consecutive primary malignant melanomas, 30 lymph nodes, 16 in‐transit and 14 visceral metastases. A series of 10 normal skin, 10 blue nevi and 10 dermal nevi was used as control. CD147 expression was assessed by immunohistochemistry, and the association of its expression with the clinicopathological characteristics of patients and survival was evaluated using univariate and multivariate statistical analyses. Univariate analysis showed that high CD147 expression was significantly associated with metastatic potential and with a reduced overall survival (P < 0.05 for both) in primary melanoma patients. CD147 expression level was correlated with histological factors which were associated with prognosis: Clark level, ulceration status and more particularly with Breslow index (r = 0.7, P < 10?8). Multivariate analysis retained CD147 expression level and ulceration status as predicting factors for metastasis and overall survival (P < 0.05 for both). CD147 emerges as an important factor in the aggressive behaviour of melanoma and deserves further evaluation as an independent prognostic biomarker. 相似文献
67.
Annie Leprêtre Idrissa Ba Karine Lacombe Maryvonne Maynart Abdalla Toufik Ousseynou Ndiaye Coumba Toure Kane Joël Gozlan Judicaël Tine Ibrahim Ndoye Gilles Raguin Pierre‐Marie Girard 《Journal of the International AIDS Society》2015,18(1)
Objectives
Data on the extent of drug use and associated HIV, hepatitis C and hepatitis B infection in West Africa are lacking. The objectives of ANRS12244 UDSEN study were to estimate the size of the heroin and/or cocaine drug user (DU) population living in the Dakar area (Senegal), and assess the prevalence and risk factors of HIV, hepatitis C virus (HCV) and hepatitis B virus (HBV), including behavioural determinants in this population, in order to set up an integrated prevention and treatment programme for DUs.Design and methods
A capture-recapture method was applied for population size estimation, whereas the respondent-driven sampling (RDS) method was used to recruit a sample of DUs living in the Dakar area and determine HIV, HBV and HCV prevalence. Behavioural data were gathered during face-to-face interviews, and blood samples were collected on dried blood spots for analysis in a central laboratory. Data analysis was performed using the RDS analysis tool, and risk factors were determined by logistic regression. Access to laboratory results was organized for the participants.Results
The size of the DU population in the Dakar area was estimated to reach 1324 (95% confidence interval (95% CI: 1281–1367)). Based on the 506 DUs included in the study, the HIV, HCV and HBV prevalence were 5.2% (95% CI: 3.8–6.3), 23.3% (95% CI: 21.2–25.2) and 7.9% (95% CI: 5.2–11.1), respectively. In people who inject drugs (PWID), prevalence levels increased to 9.4% for HIV and 38.9% for HCV (p=0.001 when compared to those who never injected). Women were more at risk of being HIV infected (prevalence: 13.04% versus 2.97% in males, p=0.001). Being PWID was a risk factor for HCV and HIV infection (odds ratio, OR: 2.7, 95% CI: 1.7–4.3, and OR: 4.3, 95% CI: 1.7–10.7, respectively), whereas older age and female sex were additional risk factors for HIV infection (10% increase per year of age, p=0.03 and OR: 4.9, 95% CI: 1.6–156, respectively). No specific determinant was associated with the risk of HBV infection.Conclusions
High HIV and HCV prevalence were estimated in this population of DUs (including non-injectors) living in the Dakar area, Senegal, whereas HBV prevalence was close to that of the global Senegalese population, reflecting a risk of infection independent of drug use. Women seem to be highly vulnerable and deserve targeted interventions for decreasing exposure to HIV, while behavioural risk factors for HIV and HCV include the use of unsafe injections, reflecting the urgent need for developing harm reduction interventions and access to opioid substitution therapy services. 相似文献68.
69.
70.